"Normal" serum ferritin--another caution [letter]

"Normal" serum ferritin--a caution.

Serum ferritin concentration and iron stores in normal subjects.

The relationship between serum ferritin concentration and the amount of storage iron has been studied in normal subjects. A high degree of correlation was demonstrated between serum ferritin concentration and storage iron measured by quantitative phlebotomy. The possible advantages of assessing iron stores by using the serum ferritin concentration are discussed.

Serum ferritin.

(1) Brief introduction to iron metabolism and the biochemistry of ferritin. (2) Early studies of circulating ferritin. (3) Methods for measuring serum ferritin concentrations -- immunoradiometric, radioimmuno- and enzyme-linked immuno assays based on liver or spleen ferritin -- an evaluation of these techniques. (4) Serum ferritin concentrations in normal subjects -- definition of normality -- ...

Radioimmunoassay of serum ferritin.

Purified human spleen ferritin was labelled with 125I. On Sepharose 6-B gel filtration four species of labelled products were separated: a component with a higher molecular weight than ferritin; a component which is eluted in the same volume as unlabelled ferritin; and two labelled compounds with molecular weights lower than ferritin. When these labelled materials were used in a double antibody...

Transformation rate between ferritin and hemosiderin assayed by serum ferritin kinetics in patients with normal iron stores and iron overload

Ferritin iron, hemosiderin iron, total iron stores and transformation rate were determined by serum ferritin kinetics. The transformation rate between ferritin and hemosiderin is motivated by the potential difference between them. The transformer determines transformation rate according to the potential difference in iron mobilization and deposition. The correlations between transformation rate...